I thought we weren't allowed to pick games once they had kicked off. Thought they would count as misses. 
We decided (and Skunky did not overrule us) that we would allow picks for Saturday to be counted as long as they came in by Thursday night. Picks for Thursday night's games that come in after kickoff are counted as a dnp (did not play).
There was at least one occasion where we counted picks posted on Friday in an exceptional case (power/Internet problem due to a hurricane).
Otherwise, I don't think any picks should allowed to be posted or edited after Thursday. People who post/edit this late get the advantage of hearing the latest opinions of the sports prognosticators.
Skunky, this is of course your game. We defer to your ruling on this.
BTW what takes us the most time is going back and looking for edited posts that we've already entered into the spreadsheet. We'd prefer that people who make changes on Thursday do a new post rather than editing an old one.