You probably know the answer, but I'll play. Western countries have been effing up the ME for centuries. In reality, the Brits are the true villains. They've created more false nations than they ever knew what to do with.
But if you want to look at the US and screwing up the ME, you really need to go back to the overthrow of a democratically elected regime of Mohammad Mosaddegh in Iran and installing our guy, the Shah. That was kind of the Brits idea as well, but we willingly played along. Not much has gone right in our ME policy since then.
Now, I'm sure you were thinking: I'll take George W. Bush for $2,000 Alec. But that would be such a silly and uneducated answer, I'd know you were just trying to rope someone in.
Actually I was waiting to see if anyone could admit that the cluster started after WWII when we decided that we could simply carve up tribal land, draw imaginary lines and nothing bad would ever happen.
Personally I'd like to see us just leave the ME and never look back. Yes, there is the possibility they could try to attack us, but ultimately leaving them alone is the best policy; and I think in the long run they'd be more consumed with fighting themselves. We've only ever been attacked because we provoked it. That doesn't make it right, but it's the truth.