I've known some great purebred dogs too, but there were many assorted health problems that IMO were due to overbreeding. One dog we had was allergic to freshly cut grass!!!
A think a little genetic variety is good for both people and dogs!
well, I think its pretty well known that certain breeds are prone to certain problems due to overbreeding or other reasons. my first lab had skin allergies, and my second one (lulu) has hay fever whenever I have hay fever during certain times of the year. but it really made no difference in their overall health, etc, as long as I provide medical or other attention as needed (if I don't watch it, lulu will get an ear infection due to her allergies). the mixed breed can inherit any of these typical doggie problems as well.
I have known some pretty great mixed breed dogs. I have known some that were not so great - and at least two not reliable or trusted near children. in other words, they can be good and they can be bad as far as traits, health, etc.... mixed breed = mixed results. even with mixed, you need to do some homework. there are resources to help you to predict size, temperament, health, etc., based on the mix - but typically we don't really know who papa dawg is...
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pain in the ass dog! well, they do exist. just like people.