Here is a nice read for those interested in hormone replacement therapy from an unbiased source. 30-A S.A.
Another Look at Using Hormones to Treat Menopausal Symptoms
If your menopausal symptoms are interfering with your life, hormone treatments might be an option; to make an informed decision, discuss your personal situation with your clinician.
Remember the Women?s Health Initiative (WHI)? In that large study of women who used hormones (estrogen and progestin) after menopause, researchers found that hormone therapy for 5 to 7 years generally was more harmful than it was helpful. After this information was released, many clinicians (doctors, nurse practitioners, nurse midwives, and physician assistants) were reluctant to prescribe hormones for women experiencing menopausal symptoms, and women themselves were afraid to take hormones, even if their symptoms interfered with their lives. Knowing a few key terms (defined in Table 1) can help you to understand which information might apply to you.
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Table 1. Menopause Terms
WHY RECONSIDER HORMONE THERAPY?
Estrogen is still the most effective treatment for hot flashes and vaginal dryness; therefore, researchers have continued to ask whether hormones are safe for certain women. The WHI revealed some important problems: More women using combination estrogen-progestin experienced heart attacks, blood clots, strokes, and breast cancers; and more women using estrogen alone developed blood clots and strokes than did comparable nonusers. The number of serious problems was small but real.
However, we now recognize that the safety of hormones is related to the age of the user. Most of the women in the WHI entered the study about 10 years after their periods had ended (older menopausal women). In contrast, most women who have severe menopausal symptoms are younger ? and the WHI participants who began HT soon after menopause were not more likely than were nonusers to develop heart disease or to die. In general, participants did not develop problems until they had used hormones for 5 years or longer. Therefore the study results probably do not apply to women who use hormones right around the time their periods stop and who use them for fewer than 5 years.
USING HORMONES TO RELIEVE SYMPTOMS
Although HT does not prevent heart disease or Alzheimer disease, it works very well for the most common symptoms of menopause. Estrogen used alone can cause abnormal changes in the uterine lining, so progestin is combined with estrogen to prevent these changes when the woman has a uterus. For women who have had hysterectomies (surgery to remove the uterus), estrogen can be used alone. Estrogen-progestin combinations and estrogen alone are available by prescription as pills, patches, gels, and sprays, as well as vaginal creams, tablets, and rings. All formulations are effective, and none has any clear advantage over the others for symptom control, so you usually can choose what you prefer. Using the lowest effective dose and continuing for the shortest time possible is recommended. Clinicians typically start by prescribing a low hormone dose and then increase the dose if necessary. For very severe symptoms, you might begin with a higher dose, which can be lowered when symptoms improve.
You might have heard about "bioidentical hormones," which are made up (compounded) for each individual woman. Although the idea might sound appealing, there is no scientific evidence that bioidentical hormones are any safer or more effective than preparations made by drug companies, and they do not have the same safeguards.
If you take estrogen plus progestin, you will probably have some irregular vaginal bleeding. This is an expected side effect and does not mean that anything is wrong. Be aware that hot flashes will probably return when you stop taking hormones, but often they are not as severe and eventually will improve.
If vaginal dryness or painful sex is your main problem, vaginal estrogen is highly effective and is available as tablets that you insert in your vagina twice weekly, a vaginal ring that you insert once every 3 months, or vaginal cream applied several times each week. Relatively little estrogen from these products is absorbed into the bloodstream, so they do not have the same risks as hormone tablets, gels, or patches.
You should not use estrogen if you have liver or heart disease, or if you have had blood clots in your legs or lungs, cancer of the breast or uterus, or a stroke. However, other treatments are available, and you should not hesitate to ask about them.
OTHER TREATMENTS FOR MENOPAUSAL SYMPTOMS
For women who cannot tolerate or prefer not to take hormones, other treatments include some types of antidepressants as well as certain prescription medications usually used for other medical problems.
"Natural remedies" (herbal and botanical products such as soy, black cohosh, red clover, and ginseng) are available without prescription. Few studies have addressed the safety and effectiveness of these products; be cautious about using them. The National Center for Complementary and Alternative Medicine advises against using kava, which can cause liver damage.
A WORD ABOUT DEPRESSION
Women often experience depression around the time of menopause. However, whether this is due to hormonal changes or to other circumstances ? or whether HT is effective for depression ? is unclear. Many good treatments for depression are available; if you are experiencing depression, seek help from your clinician, a community mental health center or hotline, or another healthcare professional as soon as possible.
TALKING WITH YOUR CLINICIAN ABOUT MENOPAUSAL HORMONE USE
If menopausal symptoms interfere with your quality of life, talk with your clinician. To ensure enough time for discussion, consider scheduling a visit separate from your annual check-up, and bring up the issue at the beginning of your appointment. Your clinician should consider your personal likelihood that hormone use might be harmful to you. For example, if you are at high risk for a heart attack or breast cancer because of your health or family history, you and your clinician might decide that estrogen?s possible risks outweigh its benefits. If you feel that hormones would be helpful but your clinician disagrees and cannot adequately explain why, consider a second opinion.
IN SUMMARY
Not all women have menopausal symptoms severe enough to make them consider treatment. If your symptoms are making you miserable, hormone therapy might be an option. Discuss your personal situation with your clinician and make an informed decision about whether hormonal or other treatment ? or no treatment ? makes the most sense for you.
Resources
National Center for Complementary and Alternative Medicine
http://nccam.nih.gov/health/menopauseandcam/
The North American Menopause Society (NAMS)
Hormone Therapy, Menopause | Expert Advice
Hormone Therapy in the Menopausal and Postmenopausal Years: What Should You Do?
(JW Womens Health Sep 5 2002)
What We?ve Learned from the Women?s Health Initiative
(JW Womens Health May 2 2006)
Manson JE with Bassuk SS. Hot Flashes, Hormones & Your Health. New York, NY: McGraw-Hill; 2007. Dr. Manson is coauthor of a Journal Watch Women?s Health feature article on hormone therapy (JW Womens Health Jul 31 2008).
? Diane E. Judge, APN/CNP
Published in Journal Watch Women's Health July 31, 2008