I think they definitely should go ahead and confirm her. Having said that, I don't think she is particularly well qualified, will show empathy instead of following existing law and precedence and make many decisions not in the interest of the populace but in the interest of special interest groups.
The point is, she will do little to change the rulings of the court as it now stands. Instead of wasting energy and effort on a cause that is futile, save your ammunition for one that is further down the road and possibly winnable. One of two things will happen in the future. Obama will gain greater approval by the American public or he will lose their confidence. The next Supreme Court appointment will be the one that counts, not this one. He may not have a chance to make it if he continues with his spending philosophy. This one will not matter. Everything controversial will still be a 5 to 4 vote.