For our last vacation, we ended up mucking around Tampa for a couple of days- saw the Tigers spring training in Lakeland, thought the Lowry Park Zoo was very good and that the St. Petersburg Museum of Art was better than the more hyped Dali Museum (some interesting pieces, but they're so terrified of people taking pictures with cameraphones that they turn the lights down so low you can't see details in the works), and had some fun exploring local parks.
Also nice to do a little bit of big city shopping- ended up with a couple bags of non-perishables from Whole Foods and it's fun, though overstimulating, to wander through a central Florida IKEA.